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Lubabegron (LBGF) - Medicating Ingredient Brochure

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Status – Over the counter

Revised June 2022

Table of approved species and claims
Approved livestock species Approved claim(s)
(abbreviated) Table Note 1
Withdrawal time Name of
approved brand(s)
Beef cattle (steers and heifers fed in confinement) 1. For reduction of ammonia gas emissions 0 days Experior 10 Lubabegron Premix

Beef cattle

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1 Experior 10 Lubabegron Premix Lubabegron (as lubabegron fumarate) at 10 g/kg

Approved for use in meal or pelleted feeds

Claim 1

For reduction of ammonia gas emissions per kilogram of live weight and hot carcass weight in beef steers and heifers fed in confinement for slaughter during the last 14 to 91 days on feed.

Level of medicating ingredient in a complete feed

1.5 to 5.5 mg/kg (0.00015% to 0.00055%) of lubabegron in the complete diet.

Note (not required to appear on medicated feed labels)

Directions for use in a complete feed

This medicated feed containing lubabegron should be fed continuously as the sole ration to beef steers and heifers fed in confinement during the last 14 to 91 days prior to slaughter.

Additional information (not to appear on feed labels)

For feed manufacturers

Additional information to be added as notes to feed labels

  1. Lubabegron may contribute to decreased marbling scores when fed for the maximum duration of 91 days.
  2. Must be thoroughly mixed in feeds before use (Required on premix and supplement labels only).
  3. Do not feed undiluted.
  4. Do not feed as a top dressing.
  5. The effectiveness of lubabegron has not been demonstrated when fed for less than 14 days.
  6. Ammonia gas emissions were measured for individual animals or small groups of animals held in environmentally controlled facilities. Based on existing information, reliable predictions of the reduction of ammonia gas emissions cannot be made on a herd, farm, or larger scale.
  7. Increased rate of weight, improved feed efficiency, and increased carcass leanness have not been demonstrated with this product.

Additional information to be added as notes to feed labels

The feeding period referred to in claim 1 as "the last 14 to 91 days on feed" should be interpreted as meaning that lubabegron can be fed to beef steers and heifers kept in confinement any time between 91 to 14 days prior to slaughter and that it can be fed up to and until the time of slaughter.

Warning

  1. No withdrawal period is required for beef steers and heifers when treated at the recommended dose of 1.5 to 5.5 mg/kg (0.00015% to 0.00055%) of lubabegron in the complete diet for a period of 14 to 91 days prior to slaughter.
  2. Do not use in calves to be processed for veal.
  3. Do not use in lactating dairy cattle.
  4. Lubabegron is a selective beta-adrenergic modulator (agonist and antagonist). Individuals with cardiovascular disease should exercise special caution to avoid exposure.
  5. Lubabegron poses a low dust potential under usual conditions of handling and mixing. When mixing and handling lubabegron, avoid inhalation, oral exposure and direct contact with eyes or skin. Use protective clothing, impervious gloves and an approved dust mask. Operators should wash thoroughly with soap and water after handling.
  6. If accidental eye or skin contact occurs, immediately rinse thoroughly with water. If wearing contact lenses, rinse eyes first, then remove contact lenses and continue to rinse for 5 to 20 minutes. If irritation persists, seek medical attention.
  7. Not for use in humans.
  8. Keep out of reach of children (Required on premix and supplement labels).
Caution
  1. Do not use in animals intended for breeding because safety and effectiveness have not been evaluated in these animals.
  2. Do not use concurrently with beta-adrenergic agonists such as ractopamine hydrochloride and zilpaterol hydrochloride.
  3. Do not allow horses or other equines access to feed containing lubabegron.
  4. A decrease in dry matter intake may be noticed in some animals.

Accepted Compatibilities

Lubabegron is compatible in single combination with any of the following drugs. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Lubabegron (beef cattle)
Name of medicating ingredient MIB code Name of approved brand(s) Applicable claims
For feedlot heifers:
Melengesterol acetate
MGAF
  1. MGA 100 Premix
Claim 1
Monensin MOS
  1. Coban Premix
  2. Monensin Premix
  3. Rumensin Premix
  4. Monovet Monensin Premix
Claim 1
Tylosin TYL
  1. Pharmasin 40 Tylosin Phosphate Premix
  2. Pharmasin 100 Tylosin Phosphate Premix
  3. Tylan 40 Tylosin Phosphate Premix
  4. Tylan 100 Tylosin Phosphate Premix
  5. Tylosin 10 Tylosin Phosphate Premix
  6. Tylosin 40 Tylosin Phosphate Premix
  7. Tylosin 100 Tylosin Premix
Claim 1

Lubabegron is compatible with multiple drugs in the following combination. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Lubabegron (beef cattle)
Name of medicating ingredient MIB code Name of approved brand(s) Applicable claims
For feedlot heifers:
Melengesterol acetate, and with
MGAF
  1. MGA 100 Premix
Claim 1
Monensin, and with MOS
  1. Monensin Premix
  2. Coban Premix
  3. Rumensin Premix
Claim 1
Tylosin TYL
  1. Pharmasin 40 Tylosin Phosphate Premix
  2. Pharmasin 100 Tylosin Phosphate Premix
  3. Tylan 40 Tylosin Phosphate Premix
  4. Tylan 100 Tylosin Phosphate Premix
  5. Tylosin 10 Tylosin Phosphate Premix
  6. Tylosin 40 Tylosin Phosphate Premix
  7. Tylosin 100 Tylosin Premix
Claim 1
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