Tilmicosin - MIB #80

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Revised date: March 2017

Approved Brands

  1. PULMOTIL Premix contains tilmicosin at 200 g/kg (Elanco)
  2. TILMOVET Premix contains tilmicosin at 200 g/kg (Huvepharma)
  3. TILMICOSIN 200 Premix contains tilmicosin at 200 g/kg (Bio Agri Mix LP)

Approved for use

In meal or pellet feed for swine, feedlot beef cattle and rabbit feeds.

Approved claims

For swine - Claims 1 and 2 approved with the use of all Premixes.
For feedlot beef cattle - Claim 3 approved with the use of all Premixes.
For rabbits - Claim 4 approved with the use of Pulmotil and Tilmicosin 200 Premixes.

Claim 1: As an aid in reducing the severity of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae and Pasteurella multocida when fed to pigs approximately 7 days prior to an anticipated disease outbreak.

Level of Drug:

200 mg/kg (0.02%) of tilmicosin in the complete feed

Note to User (Not required on feed labels): To promote responsible use and limit the development of antimicrobial resistance, consult your veterinarian and use only when factors associated with outbreaks of SRD and Glasser's Disease (such as herd health status, target pig population, herd management and environment factors, etc.) have been carefully considered.

Directions:

The medicated feed is to be fed continuously as the sole ration for a 21 day period beginning approximately 7 days before an anticipated disease outbreak.

Warning:

  1. Treated swine must not be slaughtered for use in food for at least 14 days after the latest treatment with this medicated feed.
  2. Keep out of reach of children. (Required on Premix and Supplement labels only).
  3. To limit the development of antimicrobial resistance, tilmicosin should only be used in swine at a high risk of developing SRD or Glasser's Disease.

Caution:

  1. Do not use in any feed containing bentonite. (Required on Premix and Supplement labels only).
  2. Do not use in animals hypersensitive to tilmicosin.
  3. Do not allow horses or other equines access to feeds containing tilmicosin. Ingestion of tilmicosin by these species is known to be toxic.
  4. The safety of tilmicosin has not been established in boars used for breeding.

Claim 2: As an aid in reducing the severity of porcine polyserositis and arthritis associated with Haemophilus parasuis (Glasser's Disease) when fed to pigs approximately 7 days prior to an anticipated disease outbreak.

Level of Drug:

400 mg/kg (0.04%) of tilmicosin in the complete feed

Note to User (Not required on feed labels): To promote responsible use and limit the development of antimicrobial resistance, consult your veterinarian and use only when factors associated with outbreaks of SRD and Glasser's Disease (such as herd health status, target pig population, herd management and environment factors, etc.) have been carefully considered.

Directions:

The medicated feed is to be fed continuously as the sole ration for a 21 day period beginning approximately 7 days before an anticipated disease outbreak.

Warning:

  1. Treated swine must not be slaughtered for use in food for at least 14 days after the latest treatment with this medicated feed.
  2. Keep out of reach of children. (Required on Premix and Supplement labels only).
  3. To limit the development of antimicrobial resistance, tilmicosin should only be used in swine at a high risk of developing SRD or Glasser's Disease.

Caution:

  1. Do not use in any feed containing bentonite. (Required on Premix and Supplement labels only).
  2. Do not use in animals hypersensitive to tilmicosin.
  3. Do not allow horses or other equines access to feeds containing tilmicosin. Ingestion of tilmicosin by these species is known to be toxic.
  4. The safety of tilmicosin has not been established in boars used for breeding.

Claim 3: For the reduction of bovine respiratory disease (BRD) morbidity associated with Mannheimia haemolytica, Pasteurella multocida and/or Histophilus somni in groups of feedlot beef cattle experiencing an outbreak of BRD.

Level of Drug:

At a level in supplements, premixes and complete feeds that, when used as directed, supplies 12.5 mg of tilmicosin/kg of body weight in the daily total diet, on a per head per day basis.

Note to User (Not required on feed labels): To promote responsible use and limit the development of antimicrobial resistance, consult your veterinarian and use this medication in feedlot beef cattle when:

  1. Clinical BRD has been diagnosed in at least 10% of animals in the group to be treated; and
  2. Treatment is initiated within the first 45 days of arrival in the feedlot; and
  3. Medication is limited to one single period of 14 consecutive days of treatment.

Directions:

The tilmicosin premix should be blended into an intermediate mix (premix or supplement) and then mixed into the total diet (total mixed ration). Feed continuously as a sole ration to feedlot beef cattle for a 14 day period in the total diet (total mixed ration).

Feed labels will be required to state the body weight(s) of the beef cattle being fed.

Note: Supplements, premixes, and grain rations must be thoroughly mixed in the total diet before use and must not be feed undiluted.

Warning:

  1. Treated cattle must not be slaughtered for use in food for at least 28 days after the latest treatment with this medicated feed.
  2. Do not use in lactating dairy cattle.
  3. To limit the development of antimicrobial resistance, tilmicosin should only be used in feedlot beef cattle at a high risk of developing BRD.
  4. Keep out of reach of children. (Required on Premix and Supplement labels only).

Caution:

  1. Do not use in any feed containing bentonite. (Required on Premix and Supplement labels only).
  2. The safety of tilmicosin in pre-ruminant calves has not been established.
  3. The effects of tilmicosin on bovine reproduction performance, pregnancy and lactation have not been determined.
  4. Do not use in animals hypersensitive to tilmicosin.
  5. Do not allow horses or other equines access to feeds containing tilmicosin. Ingestion of tilmicosin by these species is known to be toxic.

Claim 4: For the reduction in severity of respiratory disease caused by Pasteurella multocida in rabbits.

Level of Drug:

At a level in supplements and premixes that, when used as directed, supplies 12.5 mg of tilmicosin per kg of body weight in the total diet, which is equivalent to 200 mg/kg (0.02%) of tilmicosin in the complete feed

Note to User: (Not required on feed labels): To promote responsible use and limit the development of antimicrobial resistance, consult your veterinarian.

Directions:

The tilmicosin premix should be blended into an intermediate mix (premix or supplement) and then mixed into the total diet (total mixed ration). Feed continuously as a sole ration to rabbits for a 7-day period in the total daily ration.

NOTE: Supplements, premixes, and grain rations must be thoroughly mixed in the total ration before use and must not be feed undiluted.

WARNING:

  1. Treated rabbits must not be slaughtered for use in food for at least 4 days after the latest treatment with this drug.
  2. Keep out of reach of children. (Premix and supplement labels only.)

CAUTION:

  1. Do not use in any feed containing bentonite. (Premix and supplement labels only.)
  2. Do not use in animals hypersensitive to tilmicosin.
  3. Do not allow horses or other equines access to feeds containing tilmicosin. Ingestion of tilmicosin by these species is known to be toxic.
  4. The effects of tilmicosin on rabbit reproductive performance, pregnancy and lactation have not been determined.

Accepted Compatibilities

Tilmicosin is compatible with the following drug/drug combinations. For details, refer to the MIB as indicated.
Number Medicated ingredients For use in feed for
1. Monensin Sodium (MIB #57, Claim # 3) Feedlot beef cattle
Date modified: